a tool for identifying drug-targetable redox-active disulphides

E3 ubiquitin-protein ligase SIAH1A

Intramolecular

Cysteine 98 and cysteine 121

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase SIAH1A between cysteines 98 and 121.

Details

Redox score ?

85

PDB code

Structure name

protein-peptide complex

Structure deposition date

2005-08-11

Thiol separation (Å)

3

Half-sphere exposure sum ?

55

Minimum pK_a ?

9

% buried

14

Peptide accession

Residue number A

98

Residue number B

121

Peptide name

E3 ubiquitin-protein ligase SIAH1A

Ligandability

Cysteine 98 of E3 ubiquitin-protein ligase SIAH1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of E3 ubiquitin-protein ligase SIAH1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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